Dataset Information
Autoantibodies against a 43 KDa muscle protein in inclusion body myositis.
Ontology highlight
ABSTRACT: Background
Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease.Methodology/principal findings
Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease (N = 25) or healthy volunteer (N = 15) samples recognized this protein.Conclusions
Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis.
SUBMITTER: Salajegheh M
PROVIDER: S-EPMC3100335 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Autoantibodies against a 43 KDa muscle protein in inclusion body myositis.
PloS one 20110523 5
<h4>Background</h4>Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease.<h4>Methodology/principal findings</h4>Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa mu ...[more]
