Unknown

Dataset Information

0

Autoantibodies against a 43 KDa muscle protein in inclusion body myositis.


ABSTRACT:

Background

Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease.

Methodology/principal findings

Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease (N = 25) or healthy volunteer (N = 15) samples recognized this protein.

Conclusions

Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis.

SUBMITTER: Salajegheh M 

PROVIDER: S-EPMC3100335 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

altmetric image

Publications

Autoantibodies against a 43 KDa muscle protein in inclusion body myositis.

Salajegheh Mohammad M   Lam Theresa T   Greenberg Steven A SA  

PloS one 20110523 5


<h4>Background</h4>Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease.<h4>Methodology/principal findings</h4>Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa mu  ...[more]

Similar Datasets

| S-EPMC6465553 | biostudies-literature
2014-02-02 | E-MTAB-2141 | biostudies-arrayexpress
| S-EPMC2700211 | biostudies-literature
| S-EPMC6609472 | biostudies-literature
| S-EPMC4196838 | biostudies-other
| S-EPMC5043094 | biostudies-literature
2005-10-01 | GSE3112 | GEO
| S-EPMC6978729 | biostudies-literature
| S-EPMC9092834 | biostudies-literature
| S-EPMC9472875 | biostudies-literature