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PD-1 on dendritic cells impedes innate immunity against bacterial infection.

ABSTRACT: Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1-deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1-deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-alpha. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response.

SUBMITTER: Yao S

PROVIDER: S-EPMC2700320 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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PD-1 on dendritic cells impedes innate immunity against bacterial infection.

Yao Sheng S Wang Shengdian S Zhu Yuwen Y Luo Liqun L Zhu Gefeng G Flies Sarah S Xu Haiying H Ruff William W Broadwater Megan M Choi In-Hak IH Tamada Koji K Chen Lieping L

Blood 20090401 23

Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1-deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against letha ...[more]

PMID: 19339692

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