Ontology highlight
ABSTRACT:
SUBMITTER: Py BF
PROVIDER: S-EPMC3758559 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Immunity 20130516 5
Cochlin, an extracellular matrix protein, shares homologies with the Factor C, a serine protease found in horseshoe crabs, which is critical for antibacterial responses. Mutations in the COCH gene are responsible for human DFNA9 syndrome, a disorder characterized by neurodegeneration of the inner ear that leads to hearing loss and vestibular impairments. The physiological function of cochlin, however, is unknown. Here, we report that cochlin is specifically expressed by follicular dendritic cell ...[more]