Pathogenesis of XJ and Romero strains of Junin virus in two strains of guinea pigs.
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ABSTRACT:
SUBMITTER: Yun NE
PROVIDER: S-EPMC2700623 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Pathogenesis of XJ and Romero strains of Junin virus in two strains of guinea pigs.
Yun Nadezhda E NE Linde Nathaniel S NS Dziuba Natallia N Zacks Michele A MA Smith Jeanon N JN Smith Jennifer K JK Aronson Judy F JF Chumakova Olga V OV Lander Heather M HM Peters Clarence J CJ Paessler Slobodan S
The American journal of tropical medicine and hygiene 20080801 2
Argentine hemorrhagic fever (AHF), a systemic infectious disease caused by infection with Junin virus, affects several organs, and patients can show hematologic, cardiovascular, renal, or neurologic symptoms. We compared the virulence of two Junin virus strains in inbred and outbred guinea pigs with the aim of characterizing this animal model better for future vaccine/antiviral efficacy studies. Our data indicate that this passage of the XJ strain is attenuated in guinea pigs. In contrast, the R ...[more]
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