Ontology highlight
ABSTRACT:
SUBMITTER: Tycowski KT
PROVIDER: S-EPMC2700737 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Tycowski Kazimierz T KT Shu Mei-Di MD Kukoyi Abiodun A Steitz Joan A JA
Molecular cell 20090312 1
Small Cajal body (CB)-specific RNPs (scaRNPs) function in posttranscriptional modification of small nuclear (sn)RNAs. An RNA element, the CAB box, facilitates CB localization of H/ACA scaRNPs. Using a related element in Drosophila C/D scaRNAs, we purified a fly WD40 repeat protein that UV crosslinks to RNA in a C/D CAB box-dependent manner and associates with C/D and mixed domain C/D-H/ACA scaRNAs. Its human homolog, WDR79, associates with C/D, H/ACA, and mixed domain scaRNAs, as well as with te ...[more]