Ontology highlight
ABSTRACT:
SUBMITTER: He XJ
PROVIDER: S-EPMC2700824 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
He Xin-Jian XJ Hsu Yi-Feng YF Zhu Shihua S Wierzbicki Andrzej T AT Pontes Olga O Pikaard Craig S CS Liu Hai-Liang HL Wang Co-Shine CS Jin Hailing H Zhu Jian-Kang JK
Cell 20090501 3
DNA methylation is a conserved epigenetic mark in plants and mammals. In Arabidopsis, DNA methylation can be triggered by small interfering RNAs (siRNAs) through an RNA-directed DNA methylation (RdDM) pathway. Here, we report the identification of an RdDM effector, KTF1. Loss-of-function mutations in KTF1 reduce DNA methylation and release the silencing of RdDM target loci without abolishing the siRNA triggers. KTF1 has similarity to the transcription elongation factor SPT5 and contains a C-term ...[more]