Ontology highlight
ABSTRACT:
SUBMITTER: Sohka T
PROVIDER: S-EPMC2700907 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Sohka Takayuki T Heins Richard A RA Phelan Ryan M RM Greisler Jennifer M JM Townsend Craig A CA Ostermeier Marc M
Proceedings of the National Academy of Sciences of the United States of America 20090605 25
The current paradigm for tuning synthetic biological systems is through re-engineering system components. Biological systems designed with the inherent ability to be tuned by external stimuli will be more versatile. We engineered Escherichia coli cells to behave as an externally tunable band-pass filter for enzyme activity and small molecules. The band's location can be positioned within a range of 4 orders of magnitude simply by the addition of compounds to the growth medium. Inclusion in the g ...[more]