Ontology highlight
ABSTRACT:
SUBMITTER: Tan C
PROVIDER: S-EPMC3472685 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Molecular systems biology 20120101
The inoculum effect (IE) refers to the decreasing efficacy of an antibiotic with increasing bacterial density. It represents a unique strategy of antibiotic tolerance and it can complicate design of effective antibiotic treatment of bacterial infections. To gain insight into this phenomenon, we have analyzed responses of a lab strain of Escherichia coli to antibiotics that target the ribosome. We show that the IE can be explained by bistable inhibition of bacterial growth. A critical requirement ...[more]