Ontology highlight
ABSTRACT:
SUBMITTER: Yunk L
PROVIDER: S-EPMC2700953 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Yunk Lenka L Meng Wenzhao W Cohen Philip L PL Eisenberg Robert A RA Luning Prak Eline T ET
Journal of immunology (Baltimore, Md. : 1950) 20090701 1
Studies in autoantibody transgenic mice have demonstrated receptor editing rearrangements at Ab H and L chain loci. However, the physiologic role of H chain editing (V(H) replacement and rearrangement on the second allele) has been called into question. It is unclear if additional rounds of H chain rearrangement are driven by BCR specificity. In this study, we analyze the manner in which B cells undergo additional H chain rearrangements in an anti-DNA H chain knock-in mouse, B6.56R. We find that ...[more]