Ontology highlight
ABSTRACT:
SUBMITTER: Cho RW
PROVIDER: S-EPMC2701195 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Cho Richard W RW Park Joo Min JM Wolff Steffen B E SB Xu Desheng D Hopf Carsten C Kim Jin-Ah JA Reddy Radhika C RC Petralia Ronald S RS Perin Mark S MS Linden David J DJ Worley Paul F PF
Neuron 20080301 6
Matrix metalloproteases (MMPs) play a role in remodeling the extracellular matrix during brain development and have been implicated in synaptic plasticity. Here, we report that a member of the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR), undergoes regulated cleavage by the MMP tumor necrosis factor-alpha converting enzyme (TACE). NPR is enriched at excitatory synapses where it associates with AMPA-type glutamate receptors (AMPAR) and enhances synaptogenesis. However, in res ...[more]