Ontology highlight
ABSTRACT:
SUBMITTER: Tape CJ
PROVIDER: S-EPMC3078358 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Tape Christopher J CJ Willems Sofie H SH Dombernowsky Sarah L SL Stanley Peter L PL Fogarasi Marton M Ouwehand Willem W McCafferty John J Murphy Gillian G
Proceedings of the National Academy of Sciences of the United States of America 20110317 14
Proteolytic release from the cell surface is an essential activation event for many growth factors and cytokines. TNF-α converting enzyme (TACE) is a membrane-bound metalloprotease responsible for solubilizing many pathologically significant membrane substrates and is an attractive therapeutic target for the treatment of cancer and arthritis. Prior attempts to antagonize cell-surface TACE activity have focused on small-molecule inhibition of the metalloprotease active site. Given the highly cons ...[more]