Ontology highlight
ABSTRACT:
SUBMITTER: Onishi A
PROVIDER: S-EPMC2701228 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Onishi Akishi A Peng Guang-Hua GH Hsu Chengda C Alexis Uel U Chen Shiming S Blackshaw Seth S
Neuron 20090101 2
Specification of retinal rod photoreceptors is determined by several different transcription factors that activate expression of rod-specific genes and repress expression of cone photoreceptor-specific genes. The mechanism by which this dual regulation occurs is unclear. We have found that Pias3, a transcriptional coregulator and E3 SUMO ligase that is selectively expressed in developing photoreceptors, promotes the differentiation of rod photoreceptors while preventing rods from adopting cone p ...[more]