Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation.
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ABSTRACT:
SUBMITTER: Onishi A
PROVIDER: S-EPMC2932661 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation.
Onishi Akishi A Peng Guang-Hua GH Chen Shiming S Blackshaw Seth S
Nature neuroscience 20100822 9
Selective expression of retinal cone opsin genes is essential for color vision, but the mechanism mediating this process is poorly understood. Both vertebrate rod and medium wavelength-sensitive (M) cone photoreceptors differentiate by repression of a short wavelength-sensitive (S) cone differentiation program. We found that Pias3 acts in mouse cone photoreceptors to activate expression of M opsin and repress expression of S opsin, with the transcription factors Trbeta2 and Rxrgamma mediating pr ...[more]
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