Unknown

Dataset Information

0

Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation.


ABSTRACT: Selective expression of retinal cone opsin genes is essential for color vision, but the mechanism mediating this process is poorly understood. Both vertebrate rod and medium wavelength-sensitive (M) cone photoreceptors differentiate by repression of a short wavelength-sensitive (S) cone differentiation program. We found that Pias3 acts in mouse cone photoreceptors to activate expression of M opsin and repress expression of S opsin, with the transcription factors Trbeta2 and Rxrgamma mediating preferential expression of Pias3 in M cones. Finally, we observed that Pias3 directly regulated M and S cone opsin expression by modulating the cone-enriched transcription factors Rxrgamma, Roralpha and Trbeta1. Our results indicate that Pias3-dependent SUMOylation of photoreceptor-specific transcription factors is a common mechanism that controls both rod and cone photoreceptor subtype specification, regulating distinct molecular targets in the two cell types.

SUBMITTER: Onishi A 

PROVIDER: S-EPMC2932661 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation.

Onishi Akishi A   Peng Guang-Hua GH   Chen Shiming S   Blackshaw Seth S  

Nature neuroscience 20100822 9


Selective expression of retinal cone opsin genes is essential for color vision, but the mechanism mediating this process is poorly understood. Both vertebrate rod and medium wavelength-sensitive (M) cone photoreceptors differentiate by repression of a short wavelength-sensitive (S) cone differentiation program. We found that Pias3 acts in mouse cone photoreceptors to activate expression of M opsin and repress expression of S opsin, with the transcription factors Trbeta2 and Rxrgamma mediating pr  ...[more]

Similar Datasets

| S-EPMC2701228 | biostudies-literature
2011-09-09 | E-GEOD-24083 | biostudies-arrayexpress
2011-09-10 | GSE24083 | GEO
| S-EPMC2064872 | biostudies-literature
| S-EPMC3359287 | biostudies-literature
| S-EPMC6078599 | biostudies-literature
| S-EPMC8179201 | biostudies-literature
| S-EPMC3969374 | biostudies-literature
| S-EPMC5881442 | biostudies-literature
| S-EPMC7722777 | biostudies-literature