Ontology highlight
ABSTRACT:
SUBMITTER: Sanna S
PROVIDER: S-EPMC2701337 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Human molecular genetics 20090506 14
Bilirubin, resulting largely from the turnover of hemoglobin, is found in the plasma in two main forms: unconjugated or conjugated with glucuronic acid. Unconjugated bilirubin is transported into hepatocytes. There, it is glucuronidated by UGT1A1 and secreted into the bile canaliculi. We report a genome wide association scan in 4300 Sardinian individuals for total serum bilirubin levels. In addition to the two known loci previously involved in the regulation of bilirubin levels, UGT1A1 (P = 6.2 ...[more]