Ontology highlight
ABSTRACT:
SUBMITTER: van Dijk R
PROVIDER: S-EPMC5431759 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
van Dijk Remco R Aronson Sem J SJ de Waart Dirk R DR van de Graaf Stan F SF Duijst Suzanne S Seppen Jurgen J Elferink Ronald Oude RO Beuers Ulrich U Bosma Piter J PJ
Scientific reports 20170510 1
We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit human and rat BVRA activity and 26 compounds were identified as BVRA inhibitors. Montelukast and Disulfiram were selected as potentially clinically applicable drugs and tested to reduce serum unconjugated bilirubin (UCB) levels in the Ugt1a1-deficient rat, a model for ...[more]