Ontology highlight
ABSTRACT:
SUBMITTER: Stephan AB
PROVIDER: S-EPMC2702256 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Stephan Aaron B AB Shum Eleen Y EY Hirsh Sarah S Cygnar Katherine D KD Reisert Johannes J Zhao Haiqing H
Proceedings of the National Academy of Sciences of the United States of America 20090626 28
For vertebrate olfactory signal transduction, a calcium-activated chloride conductance serves as a major amplification step. However, the molecular identity of the olfactory calcium-activated chloride channel (CaCC) is unknown. Here we report a proteomic screen for cilial membrane proteins of mouse olfactory sensory neurons (OSNs) that identified all the known olfactory transduction components as well as Anoctamin 2 (ANO2). Ano2 transcripts were expressed specifically in OSNs in the olfactory ep ...[more]