Ontology highlight
ABSTRACT:
SUBMITTER: Lam AKM
PROVIDER: S-EPMC7862263 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Lam Andy K M AKM Dutzler Raimund R
Nature communications 20210204 1
The anion channel TMEM16A is activated by intracellular Ca<sup>2+</sup> in a highly cooperative process. By combining electrophysiology and autocorrelation analysis, we investigated the mechanism of channel activation and the concurrent rearrangement of the gate in the narrow part of the pore. Features in the fluctuation characteristics of steady-state current indicate the sampling of intermediate conformations that are successively occupied during gating. The initial step is related to conforma ...[more]