Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.
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ABSTRACT:
SUBMITTER: Wilker E
PROVIDER: S-EPMC2702409 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.
Wilker Elissa E Mittleman Murray A MA Litonjua Augusto A AA Poon Audrey A Baccarelli Andrea A Suh Helen H Wright Robert O RO Sparrow David D Vokonas Pantel P Schwartz Joel J
Environmental health perspectives 20090203 6
<h4>Background</h4>Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation.<h4>Objective</h4>We hypothesized that PM(2.5) influences postural changes in systolic blood pressure (DeltaSBP) and in diastolic blood pressure (DeltaDBP) and that this effect is modified by genes thought to be related to chronic lung disease.<h4>Methods</h4>We measured blood pressure in participants every 3-5 years. DeltaSBP and DeltaDBP were calculated as si ...[more]
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