Ontology highlight
ABSTRACT:
SUBMITTER: Schneider K
PROVIDER: S-EPMC2703178 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Schneider Kirsten K Loewendorf Andrea A De Trez Carl C Fulton James J Rhode Antje A Shumway Heather H Ha Sukwon S Patterson Ginelle G Pfeffer Klaus K Nedospasov Sergei A SA Ware Carl F CF Benedict Chris A CA
Cell host & microbe 20080201 2
Toll-like receptor (TLR)-dependent pathways control the production of IFNalphabeta, a key cytokine in innate immune control of viruses including mouse cytomegalovirus (MCMV). The lymphotoxin (LT) alphabeta-LTbeta receptor signaling pathway is also critical for defense against MCMV and thought to aid in the IFNbeta response. We find that upon MCMV infection, mice deficient for lymphotoxin (LT)alphabeta signaling cannot mount the initial part of a biphasic IFNalphabeta response, but show normal le ...[more]