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The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.

ABSTRACT: The Lymphotoxin (LT) pathway is best known for its role in orchestrating the development and homeostasis of lymph nodes and Peyer's patches through the regulation of homeostatic chemokines. More recently an appreciation of the LT?R pathway in the production of Type I interferons (IFN-I) during homeostasis and infection has emerged. LT?R signaling is essential in differentiating stromal cells and macrophages in lymphoid organs to rapidly produce IFN-I in response to virus infections independently of the conventional TLR signaling systems. In addition, LT?R signaling is required to produce homeostatic levels of IFN-I from dendritic cells in order to effectively cross-prime a CD8+ T cell response to protein antigen. Importantly, pharmacological inhibition of LT?R signaling in mice has a profound positive impact on a number of autoimmune disease models, although it remains unclear if this efficacy is linked to IFN-I production during chronic inflammation. In this review, we will provide a brief overview of how the "Lymphotoxin Network" is linked to the IFN-I response and its impact on the immune system.

SUBMITTER: Gommerman JL

PROVIDER: S-EPMC4081445 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.

Gommerman Jennifer L JL Browning Jeffrey L JL Ware Carl F CF

Cytokine & growth factor reviews 20140312 2

The Lymphotoxin (LT) pathway is best known for its role in orchestrating the development and homeostasis of lymph nodes and Peyer's patches through the regulation of homeostatic chemokines. More recently an appreciation of the LTβR pathway in the production of Type I interferons (IFN-I) during homeostasis and infection has emerged. LTβR signaling is essential in differentiating stromal cells and macrophages in lymphoid organs to rapidly produce IFN-I in response to virus infections independently ...[more]

PMID: 24698108

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Dataset Information

The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.

Publications

The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.

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