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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.


ABSTRACT: To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

SUBMITTER: Ferreira MA 

PROVIDER: S-EPMC2703780 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature

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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

Ferreira Manuel A R MA   O'Donovan Michael C MC   Meng Yan A YA   Jones Ian R IR   Ruderfer Douglas M DM   Jones Lisa L   Fan Jinbo J   Kirov George G   Perlis Roy H RH   Green Elaine K EK   Smoller Jordan W JW   Grozeva Detelina D   Stone Jennifer J   Nikolov Ivan I   Chambert Kimberly K   Hamshere Marian L ML   Nimgaonkar Vishwajit L VL   Moskvina Valentina V   Thase Michael E ME   Caesar Sian S   Sachs Gary S GS   Franklin Jennifer J   Gordon-Smith Katherine K   Ardlie Kristin G KG   Gabriel Stacey B SB   Fraser Christine C   Blumenstiel Brendan B   Defelice Matthew M   Breen Gerome G   Gill Michael M   Morris Derek W DW   Elkin Amanda A   Muir Walter J WJ   McGhee Kevin A KA   Williamson Richard R   MacIntyre Donald J DJ   MacLean Alan W AW   St Clair David CD   Robinson Michelle M   Van Beck Margaret M   Pereira Ana C P AC   Kandaswamy Radhika R   McQuillin Andrew A   Collier David A DA   Bass Nicholas J NJ   Young Allan H AH   Lawrence Jacob J   Ferrier I Nicol IN   Anjorin Adebayo A   Farmer Anne A   Curtis David D   Scolnick Edward M EM   McGuffin Peter P   Daly Mark J MJ   Corvin Aiden P AP   Holmans Peter A PA   Blackwood Douglas H DH   Gurling Hugh M HM   Owen Michael J MJ   Purcell Shaun M SM   Sklar Pamela P   Craddock Nick N  

Nature genetics 20080901 9


To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. ...[more]

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