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Genome-wide association study identifies 30 loci associated with bipolar disorder.

ABSTRACT: Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P?

SUBMITTER: Stahl EA

PROVIDER: S-EPMC6956732 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Genome-wide association study identifies 30 loci associated with bipolar disorder.

Stahl Eli A EA Breen Gerome G Forstner Andreas J AJ McQuillin Andrew A Ripke Stephan S Trubetskoy Vassily V Mattheisen Manuel M Wang Yunpeng Y Coleman Jonathan R I JRI Gaspar Héléna A HA de Leeuw Christiaan A CA Steinberg Stacy S Pavlides Jennifer M Whitehead JMW Trzaskowski Maciej M Byrne Enda M EM Pers Tune H TH Holmans Peter A PA Richards Alexander L AL Abbott Liam L Agerbo Esben E Akil Huda H Albani Diego D Alliey-Rodriguez Ney N Als Thomas D TD Anjorin Adebayo A Antilla Verneri V Awasthi Swapnil S Badner Judith A JA Bækvad-Hansen Marie M Barchas Jack D JD Bass Nicholas N Bauer Michael M Belliveau Richard R Bergen Sarah E SE Pedersen Carsten Bøcker CB Bøen Erlend E Boks Marco P MP Boocock James J Budde Monika M Bunney William W Burmeister Margit M Bybjerg-Grauholm Jonas J Byerley William W Casas Miquel M Cerrato Felecia F Cervantes Pablo P Chambert Kimberly K Charney Alexander W AW Chen Danfeng D Churchhouse Claire C Clarke Toni-Kim TK Coryell William W Craig David W DW Cruceanu Cristiana C Curtis David D Czerski Piotr M PM Dale Anders M AM de Jong Simone S Degenhardt Franziska F Del-Favero Jurgen J DePaulo J Raymond JR Djurovic Srdjan S Dobbyn Amanda L AL Dumont Ashley A Elvsåshagen Torbjørn T Escott-Price Valentina V Fan Chun Chieh CC Fischer Sascha B SB Flickinger Matthew M Foroud Tatiana M TM Forty Liz L Frank Josef J Fraser Christine C Freimer Nelson B NB Frisén Louise L Gade Katrin K Gage Diane D Garnham Julie J Giambartolomei Claudia C Pedersen Marianne Giørtz MG Goldstein Jaqueline J Gordon Scott D SD Gordon-Smith Katherine K Green Elaine K EK Green Melissa J MJ Greenwood Tiffany A TA Grove Jakob J Guan Weihua W Guzman-Parra José J Hamshere Marian L ML Hautzinger Martin M Heilbronner Urs U Herms Stefan S Hipolito Maria M Hoffmann Per P Holland Dominic D Huckins Laura L Jamain Stéphane S Johnson Jessica S JS Juréus Anders A Kandaswamy Radhika R Karlsson Robert R Kennedy James L JL Kittel-Schneider Sarah S Knowles James A JA Kogevinas Manolis M Koller Anna C AC Kupka Ralph R Lavebratt Catharina C Lawrence Jacob J Lawson William B WB Leber Markus M Lee Phil H PH Levy Shawn E SE Li Jun Z JZ Liu Chunyu C Lucae Susanne S Maaser Anna A MacIntyre Donald J DJ Mahon Pamela B PB Maier Wolfgang W Martinsson Lina L McCarroll Steve S McGuffin Peter P McInnis Melvin G MG McKay James D JD Medeiros Helena H Medland Sarah E SE Meng Fan F Milani Lili L Montgomery Grant W GW Morris Derek W DW Mühleisen Thomas W TW Mullins Niamh N Nguyen Hoang H Nievergelt Caroline M CM Adolfsson Annelie Nordin AN Nwulia Evaristus A EA O'Donovan Claire C Loohuis Loes M Olde LMO Ori Anil P S APS Oruc Lilijana L Ösby Urban U Perlis Roy H RH Perry Amy A Pfennig Andrea A Potash James B JB Purcell Shaun M SM Regeer Eline J EJ Reif Andreas A Reinbold Céline S CS Rice John P JP Rivas Fabio F Rivera Margarita M Roussos Panos P Ruderfer Douglas M DM Ryu Euijung E Sánchez-Mora Cristina C Schatzberg Alan F AF Scheftner William A WA Schork Nicholas J NJ Shannon Weickert Cynthia C Shehktman Tatyana T Shilling Paul D PD Sigurdsson Engilbert E Slaney Claire C Smeland Olav B OB Sobell Janet L JL Søholm Hansen Christine C Spijker Anne T AT St Clair David D Steffens Michael M Strauss John S JS Streit Fabian F Strohmaier Jana J Szelinger Szabolcs S Thompson Robert C RC Thorgeirsson Thorgeir E TE Treutlein Jens J Vedder Helmut H Wang Weiqing W Watson Stanley J SJ Weickert Thomas W TW Witt Stephanie H SH Xi Simon S Xu Wei W Young Allan H AH Zandi Peter P Zhang Peng P Zöllner Sebastian S Adolfsson Rolf R Agartz Ingrid I Alda Martin M Backlund Lena L Baune Bernhard T BT Bellivier Frank F Berrettini Wade H WH Biernacka Joanna M JM Blackwood Douglas H R DHR Boehnke Michael M Børglum Anders D AD Corvin Aiden A Craddock Nicholas N Daly Mark J MJ Dannlowski Udo U Esko Tõnu T Etain Bruno B Frye Mark M Fullerton Janice M JM Gershon Elliot S ES Gill Michael M Goes Fernando F Grigoroiu-Serbanescu Maria M Hauser Joanna J Hougaard David M DM Hultman Christina M CM Jones Ian I Jones Lisa A LA Kahn René S RS Kirov George G Landén Mikael M Leboyer Marion M Lewis Cathryn M CM Li Qingqin S QS Lissowska Jolanta J Martin Nicholas G NG Mayoral Fermin F McElroy Susan L SL McIntosh Andrew M AM McMahon Francis J FJ Melle Ingrid I Metspalu Andres A Mitchell Philip B PB Morken Gunnar G Mors Ole O Mortensen Preben Bo PB Müller-Myhsok Bertram B Myers Richard M RM Neale Benjamin M BM Nimgaonkar Vishwajit V Nordentoft Merete M Nöthen Markus M MM O'Donovan Michael C MC Oedegaard Ketil J KJ Owen Michael J MJ Paciga Sara A SA Pato Carlos C Pato Michele T MT Posthuma Danielle D Ramos-Quiroga Josep Antoni JA Ribasés Marta M Rietschel Marcella M Rouleau Guy A GA Schalling Martin M Schofield Peter R PR Schulze Thomas G TG Serretti Alessandro A Smoller Jordan W JW Stefansson Hreinn H Stefansson Kari K Stordal Eystein E Sullivan Patrick F PF Turecki Gustavo G Vaaler Arne E AE Vieta Eduard E Vincent John B JB Werge Thomas T Nurnberger John I JI Wray Naomi R NR Di Florio Arianna A Edenberg Howard J HJ Cichon Sven S Ophoff Roel A RA Scott Laura J LJ Andreassen Ole A OA Kelsoe John J Sklar Pamela P

Nature genetics 20190501 5

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10<sup>-4</sup> in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 × 10<sup>-8</sup>) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes an ...[more]

PMID: 31043756

Dataset Information

Genome-wide association study identifies 30 loci associated with bipolar disorder.

Publications

Genome-wide association study identifies 30 loci associated with bipolar disorder.

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