Ontology highlight
ABSTRACT:
SUBMITTER: Maupetit J
PROVIDER: S-EPMC2703897 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Maupetit Julien J Derreumaux Philippe P Tuffery Pierre P
Nucleic acids research 20090511 Web Server issue
Rational peptide design and large-scale prediction of peptide structure from sequence remain a challenge for chemical biologists. We present PEP-FOLD, an online service, aimed at de novo modelling of 3D conformations for peptides between 9 and 25 amino acids in aqueous solution. Using a hidden Markov model-derived structural alphabet (SA) of 27 four-residue letters, PEP-FOLD first predicts the SA letter profiles from the amino acid sequence and then assembles the predicted fragments by a greedy ...[more]