Ontology highlight
ABSTRACT:
SUBMITTER: Angelastro JM
PROVIDER: S-EPMC27040 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
Angelastro J M JM Klimaschewski L L Tang S S Vitolo O V OV Weissman T A TA Donlin L T LT Shelanski M L ML Greene L A LA
Proceedings of the National Academy of Sciences of the United States of America 20000901 19
Neurotrophic factors such as nerve growth factor (NGF) promote a wide variety of responses in neurons, including differentiation, survival, plasticity, and repair. Such actions often require changes in gene expression. To identify the regulated genes and thereby to more fully understand the NGF mechanism, we carried out serial analysis of gene expression (SAGE) profiling of transcripts derived from rat PC12 cells before and after NGF-promoted neuronal differentiation. Multiple criteria supported ...[more]