Ontology highlight
ABSTRACT:
SUBMITTER: Bie B
PROVIDER: S-EPMC2865237 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Bie Bihua B Zhang Zhi Z Cai You-Qing YQ Zhu Wei W Zhang Yong Y Dai Jaile J Lowenstein Charles J CJ Weinman Edward J EJ Pan Zhizhong Z ZZ
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100401 16
Sorting of intracellular G-protein-coupled receptors (GPCRs) either to lysosomes for degradation or to plasma membrane for surface insertion and functional expression is a key process regulating signaling strength of GPCRs across the plasma membrane in adult mammalian cells. However, little is known about the molecular mechanisms governing the dynamic process of receptor sorting to the plasma membrane for functional expression under normal and pathological conditions. In this study, we demonstra ...[more]