Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC2704254 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Sun Lingyun L Akiyama Kentaro K Zhang Huayong H Yamaza Takayoshi T Hou Yayi Y Zhao Shengnan S Xu Ting T Le Anh A Shi Songtao S
Stem cells (Dayton, Ohio) 20090601 6
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. Here, we reported that impairment of bone marrow mesenchymal stem cells (BMMSCs) and their associated osteoblastic niche deficiency contribute in part to the pathogenesis of SLE-like disease in MRL/lpr mice. Interestingly, allogenic BMMSC transplantation (MSCT) is capable ...[more]