Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.

ABSTRACT: Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the bla(CMY) genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.

SUBMITTER: Doi Y 

PROVIDER: S-EPMC2704647 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature