Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
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ABSTRACT:
SUBMITTER: Doi Y
PROVIDER: S-EPMC2704647 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
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Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase.
Doi Yohei Y Paterson David L DL Adams-Haduch Jennifer M JM Sidjabat Hanna E HE O'Keefe Alexandra A Endimiani Andrea A Bonomo Robert A RA
Antimicrobial agents and chemotherapy 20090504 7
Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the bla(CMY) genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime. ...[more]
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