Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice.
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ABSTRACT:
SUBMITTER: Bennett BJ
PROVIDER: S-EPMC2704985 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice.
Bennett Brian J BJ Wang Susanna S SS Wang Xuping X Wu Xiaohui X Lusis Aldons J AJ
Arteriosclerosis, thrombosis, and vascular biology 20090102 3
<h4>Objective</h4>We sought to determine the genetic factors contributing to atherosclerotic plaque size and cellular composition in the innominate artery, a murine model of advanced atherosclerosis.<h4>Methods and results</h4>We examined genetic contributions to innominate atherosclerotic plaque size and cellular composition in an intercross between C57BL/6J.Apoe(-/-), a strain susceptible to aortic lesions, and C3H/HeJ.Apoe(-/-), a strain resistant to aortic lesions. Surprisingly, total innomi ...[more]
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