Ontology highlight
ABSTRACT:
SUBMITTER: Sengle G
PROVIDER: S-EPMC2705212 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Sengle Gerhard G Ono Robert N RN Lyons Karen M KM Bächinger Hans Peter HP Sakai Lynn Y LY
Journal of molecular biology 20080702 4
Bone morphogenetic proteins (BMPs) are morphogens with long-range signaling activities. BMP-7 is secreted as a stable complex consisting of a growth factor noncovalently associated with two propeptides. In other transforming growth factor-beta-like growth factor complexes, the prodomain (pd) confers latency to the complex. However, we detected no difference in signaling capabilities between the growth factor and the BMP-7 complex in multiple in vitro bioactivity assays. Biochemical and biophysic ...[more]