Ontology highlight
ABSTRACT:
SUBMITTER: Zhao B
PROVIDER: S-EPMC5798290 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Zhao Bo B Xu Shutong S Dong Xianchi X Lu Chafen C Springer Timothy A TA
The Journal of biological chemistry 20171105 5
TGF-β is synthesized as a proprotein that dimerizes in the endoplasmic reticulum. After processing in the Golgi to cleave the N-terminal prodomain from the C-terminal growth factor (GF) domain in each monomer, pro-TGF-β is secreted and stored in latent complexes. It is unclear which prodomain and GF monomer are linked before proprotein convertase cleavage and how much conformational change occurs following cleavage. We have determined a structure of pro-TGF-β1 with the proprotein convertase clea ...[more]