Ontology highlight
ABSTRACT:
SUBMITTER: Yuan X
PROVIDER: S-EPMC2705547 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Yuan Xueli X Ansari M Javeed MJ D'Addio Francesca F Paez-Cortez Jesus J Schmitt Isabella I Donnarumma Michela M Boenisch Olaf O Zhao Xiaozhi X Popoola Joyce J Clarkson Michael R MR Yagita Hideo H Akiba Hisaya H Freeman Gordon J GJ Iacomini John J Turka Laurence A LA Glimcher Laurie H LH Sayegh Mohamed H MH
Proceedings of the National Academy of Sciences of the United States of America 20090615 26
The ability to induce durable transplantation tolerance predictably and consistently in the clinic is a highly desired but elusive goal. Progress is hampered by lack of appropriate experimental models in which to study resistance to transplantation tolerance. Here, we demonstrate that T helper 1-associated T box 21 transcription factor (Tbet) KO recipients exhibit allograft tolerance resistance specifically mediated by IL-17-producing CD8 T (T17) cells. Neutralization of IL-17 facilitates long-t ...[more]