Ontology highlight
ABSTRACT:
SUBMITTER: Chang L
PROVIDER: S-EPMC6543058 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Chang Linlin L Hu Yan Y Fu Yingying Y Zhou Tianyi T You Jun J Du Jiamin J Zheng Lin L Cao Ji J Ying Meidan M Dai Xiaoyang X Su Dan D He Qiaojun Q Zhu Hong H Yang Bo B
Acta pharmaceutica Sinica. B 20190302 3
Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastatic-associated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of ...[more]