Ontology highlight
ABSTRACT:
SUBMITTER: Kapoor M
PROVIDER: S-EPMC2706086 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Kapoor Mili M Otero Francella J FJ Slike Bonnie M BM Ewalt Karla L KL Yang Xiang-Lei XL
Chemistry & biology 20090501 5
Aminoacyl tRNA synthetases are known for catalysis of aminoacylation. Significantly, some mammalian synthetases developed cytokine functions possibly linked to disease-causing mutations in tRNA synthetases. Not understood is how epitopes for cytokine signaling were introduced into catalytic scaffolds without disturbing aminoacylation. Here we investigate human tyrosyl-tRNA synthetase, where a catalytic-domain surface helix, next to the active site, was recruited for interleukin-8-like cytokine s ...[more]