Ontology highlight
ABSTRACT:
SUBMITTER: Wei Z
PROVIDER: S-EPMC4756856 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Wei Zhiyi Z Xu Zhiwen Z Liu Xiaotian X Lo Wing-Sze WS Ye Fei F Lau Ching-Fun CF Wang Feng F Zhou Jie J JJ Nangle Leslie A LA Yang Xiang-Lei XL Zhang Mingjie M Schimmel Paul P
Nucleic acids research 20160114 3
Many human tRNA synthetases evolved alternative functions outside of protein synthesis. These functions are associated with over 200 splice variants (SVs), most of which are catalytic nulls that engender new biology. While known to regulate non-translational activities, little is known about structures resulting from natural internal ablations of any protein. Here, we report analysis of two closely related, internally deleted, SVs of homodimeric human tyrosyl-tRNA synthetase (TyrRS). In spite of ...[more]