Ontology highlight
ABSTRACT:
SUBMITTER: Gagnidze K
PROVIDER: S-EPMC2706147 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Gagnidze Khatuna K Sachchidanand Rozenfeld Raphael R Mezei Mihaly M Zhou Ming-Ming MM Devi Lakshmi A LA
Journal of medicinal chemistry 20080529 12
Endothelin-converting enzyme-2 (ECE-2), a member of M13 family of zinc metallopeptidases, has previously been shown to process a number of neuropeptides including those derived from prodynorphin, proenkephalin, proSAAS, and amyloid precursor protein. ECE-2, unlike ECE-1, exhibits restricted neuroendocrine distribution and acidic pH optimum; it is consistent with a role in the regulation of neuropeptide levels in vivo. Here, we report the generation of a three-dimensional (3D) molecular model of ...[more]