Ontology highlight
ABSTRACT:
SUBMITTER: Toustrup-Jensen MS
PROVIDER: S-EPMC2707196 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20090505 28
The Na(+),K(+)-ATPase C terminus has a unique location between transmembrane segments, appearing to participate in a network of interactions. We have examined the functional consequences of amino acid substitutions in this region and deletions of the C terminus of varying lengths. Assays revealing separately the mutational effects on internally and externally facing Na(+) sites, as well as E(1)-E(2) conformational changes, have been applied. The results pinpoint the two terminal tyrosines, Tyr(1 ...[more]