Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease.
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ABSTRACT:
SUBMITTER: Donofrio G
PROVIDER: S-EPMC2707594 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
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Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease.
Donofrio Gaetano G Ravanetti Lara L Cavirani Sandro S Herath Shan S Capocefalo Antonio A Sheldon Iain Martin IM
Reproduction (Cambridge, England) 20080624 3
Experimental infection with the gamma-herpesvirus bovine herpesvirus 4 (BoHV-4) rarely establishes disease, yet BoHV-4 is commonly associated with uterine disease in cattle. Uterine disease involves co-infection with bacteria such as Escherichia coli, which stimulate the production of prostaglandin E(2) (PGE(2)) by endometrial cells. BoHV-4 replication depends on immediate early 2 (IE2) gene transactivation and, in the present study, PGE(2), E. coli or its lipopolysaccharide upregulated the IE2 ...[more]
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