Ontology highlight
ABSTRACT:
SUBMITTER: Anand R
PROVIDER: S-EPMC2708071 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Anand Ruchi R Maksimoska Jasna J Pagano Nicholas N Wong Eric Y EY Gimotty Phyllis A PA Diamond Scott L SL Meggers Eric E Marmorstein Ronen R
Journal of medicinal chemistry 20090301 6
Mammalian sterile 20 (MST1) kinase, a member of the sterile 20 (Ste-20) family of proteins, is a proapoptotic cytosolic kinase that plays an important role in the cellular response to oxidative stress. In this study, we report on the development of a potent and selective MST1 kinase inhibitor based on a ruthenium half-sandwich scaffold. We show that the enantiopure organoruthenium inhibitor, 9E1, has an IC50 value of 45 nM for MST1 and a greater than 25-fold inhibitor selectivity over the relate ...[more]