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Development of a Potent and Selective HDAC8 Inhibitor.

ABSTRACT: A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.

SUBMITTER: Ingham OJ

PROVIDER: S-EPMC5066159 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Development of a Potent and Selective HDAC8 Inhibitor.

Ingham Oscar J OJ Paranal Ronald M RM Smith William B WB Escobar Randolph A RA Yueh Han H Snyder Tracy T Porco John A JA Bradner James E JE Beeler Aaron B AB

ACS medicinal chemistry letters 20160901 10

A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8. ...[more]

PMID: 27774131

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