Ontology highlight
ABSTRACT:
SUBMITTER: Kilpinen H
PROVIDER: S-EPMC2708134 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Human molecular genetics 20090519 15
Population isolates, such as Finland, have proved beneficial in mapping rare causative genetic variants due to a limited number of founders resulting in reduced genetic heterogeneity and extensive linkage disequilibrium (LD). We have here used this special opportunity to identify rare alleles in autism by genealogically tracing 20 autism families into one extended pedigree with verified genealogical links reaching back to the 17th century. In this unique pedigree, we performed a dense microsatel ...[more]