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Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria japonica.


ABSTRACT: We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55 × 10(-5) and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.

SUBMITTER: Moritsuka E 

PROVIDER: S-EPMC3296249 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria japonica.

Moritsuka Etsuko E   Hisataka Yosuke Y   Tamura Miho M   Uchiyama Kentaro K   Watanabe Atsushi A   Tsumura Yoshihiko Y   Tachida Hidenori H  

Genetics 20111229 3


We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55 × 10(-5) and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies. ...[more]

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