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Decoupling of the brain's default mode network during deep sleep.

ABSTRACT: The recent discovery of a circuit of brain regions that is highly active in the absence of overt behavior has led to a quest for revealing the possible function of this so-called default-mode network (DMN). A very recent study, finding similarities in awake humans and anesthetized primates, has suggested that DMN activity might not simply reflect ongoing conscious mentation but rather a more general form of network dynamics typical of complex systems. Here, by performing functional MRI in humans, it is shown that a natural, sleep-induced reduction of consciousness is reflected in altered correlation between DMN network components, most notably a reduced involvement of frontal cortex. This suggests that DMN may play an important role in the sustenance of conscious awareness.

SUBMITTER: Horovitz SG

PROVIDER: S-EPMC2708777 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Decoupling of the brain's default mode network during deep sleep.

Horovitz Silvina G SG Braun Allen R AR Carr Walter S WS Picchioni Dante D Balkin Thomas J TJ Fukunaga Masaki M Duyn Jeff H JH

Proceedings of the National Academy of Sciences of the United States of America 20090619 27

The recent discovery of a circuit of brain regions that is highly active in the absence of overt behavior has led to a quest for revealing the possible function of this so-called default-mode network (DMN). A very recent study, finding similarities in awake humans and anesthetized primates, has suggested that DMN activity might not simply reflect ongoing conscious mentation but rather a more general form of network dynamics typical of complex systems. Here, by performing functional MRI in humans ...[more]

PMID: 19549821

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