Unknown

Dataset Information

0

A?-induced vulnerability propagates via the brain's default mode network.

ABSTRACT: The link between brain amyloid-? (A?), metabolism, and dementia symptoms remains a pressing question in Alzheimer's disease. Here, using positron emission tomography ([18F]florbetapir tracer for A? and [18F]FDG tracer for glucose metabolism) with a novel analytical framework, we found that A? aggregation within the brain's default mode network leads to regional hypometabolism in distant but functionally connected brain regions. Moreover, we found that an interaction between this hypometabolism with overlapping A? aggregation is associated with subsequent cognitive decline. These results were also observed in transgenic A? rats that do not form neurofibrillary tangles, which support these findings as an independent mechanism of cognitive deterioration. These results suggest a model in which distant A? induces regional metabolic vulnerability, whereas the interaction between local A? with a vulnerable environment drives the clinical progression of dementia.

SUBMITTER: Pascoal TA 

PROVIDER: S-EPMC6547716 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer's disease. Here, using positron emission tomography ([<sup>18</sup>F]florbetapir tracer for Aβ and [<sup>18</sup>F]FDG tracer for glucose metabolism) with a novel analytical framework, we found that Aβ aggregation within the brain's default mode network leads to regional hypometabolism in distant but functionally connected brain regions. Moreover, we found that an interaction between  ...[more]

Similar Datasets

Unknown Decoupling of the brain's default mode network during deep sleep.
| S-EPMC2708777 | biostudies-literature
Unknown Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjects.
| S-EPMC3742122 | biostudies-literature
Unknown Functional-anatomic fractionation of the brain's default network.
| S-EPMC2848443 | biostudies-literature
Unknown The maturing architecture of the brain's default network.
| S-EPMC2268790 | biostudies-literature
Unknown Differential modulation of the default mode network via serotonin-1A receptors.
| S-EPMC3289336 | biostudies-literature
Unknown Cognitive impairment in Parkinson's disease is associated with Default Mode Network subsystem connectivity and cerebrospinal fluid Aβ.
| S-EPMC7940579 | biostudies-literature
Unknown Regional excitation-inhibition balance predicts default-mode network deactivation via functional connectivity.
| S-EPMC8284909 | biostudies-literature
Unknown Task-induced deactivation from rest extends beyond the default mode brain network.
| S-EPMC3146521 | biostudies-literature
Unknown Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats.
| S-EPMC10721862 | biostudies-literature
Unknown Tormenting thoughts: The posterior cingulate sulcus of the default mode network regulates valence of thoughts and activity in the brain's pain network during music listening.
| S-EPMC8720190 | biostudies-literature