Ontology highlight
ABSTRACT:
SUBMITTER: Rawlinson SM
PROVIDER: S-EPMC2708855 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Rawlinson Stephen M SM Pryor Melinda J MJ Wright Peter J PJ Jans David A DA
The Journal of biological chemistry 20090318 23
Although all established functions of dengue virus NS5 (nonstructural protein 5) occur in the cytoplasm, its nuclear localization, mediated by dual nuclear localization sequences, is essential for virus replication. Here, we have determined the mechanism by which NS5 can localize in the cytoplasm to perform its role in replication, establishing for the first time that it is able to be exported from the nucleus by the exportin CRM1 and hence can shuttle between the nucleus and cytoplasm. We defin ...[more]