Higher serum 25-hydroxyvitamin D levels in school-age children are inconsistently associated with increased calcium absorption.

ABSTRACT:

Context

Increasing serum 25-hydroxyvitamin D (25-OHD) in adults may enhance calcium absorption (Ca-abs). There are few similar pediatric data leading to uncertainty about the optimal target for 25-OHD to maximize Ca-abs.

Objective

Our objective was to evaluate the relationship between 25-OHD and Ca-abs in a large cohort of school-age children and adolescents.

Design

We evaluated data from 439 Ca-abs measurements performed using dual-tracer stable isotope techniques conducted at our center over a 15-yr period in 251 healthy children, 4.9-16.7 yr of age.

Results

Serum 25-OHD ranged from 28 to 197 nmol/liter (mean 85 +/- 2 nmol/liter) (sem). Total Ca-abs (intake times fractional absorption) were significantly correlated to 25-OHD in the whole population (r = 0.16,

SUBMITTER: Abrams SA 

PROVIDER: S-EPMC2708956 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature