Dataset Information

Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children.

ABSTRACT:

Objective

To explore the correlation between serum 25-hydroxyvitamin D levels and tic disorders (TDs) in Chinese children.

Methods

We selected 2960 children with TD and 2665 healthy controls, aged 5-14 years, from the Department of Neurology of the Shanghai Children's Hospital. Serum 25-hydroxyvitamin D levels and degrees of vitamin D deficiency were compared between patients with TD and healthy children.

Results

The mean serum 25-hydroxyvitamin D level in the TD group was significantly lower than that in the control group (P < 0.001). The proportion of patients with 25-hydroxyvitamin D deficiency in the TD group was significantly higher than that in the control group. However, there was no correlation between 25-hydroxyvitamin D deficiency and the severity of TD. In addition, for age-wise comparison, mean levels of 25-hydroxyvitamin D and its deficiency in the TD group were the most significant in children over 9 years of age.

Conclusion

There is a correlation between 25-hydroxyvitamin D deficiency and TD in Chinese children, but not between 25-hydroxyvitamin D deficiency and the severity of TD. There was a correlation between age and deficiency of 25-hydroxyvitamin D; this deficiency was most pronounced among those over the age of 9 years.

SUBMITTER: Wang S

PROVIDER: S-EPMC9124939 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children.

Wang Simei S Xu Quanmei Q Wang Anqi A Yuan Fang F Luo Xiaona X Wang Yilin Y Guo Miao M Zhang Yuanfeng Y Zhang Wenjing W Ji Xiaobing X Ren Yun Y Chen Yucai Y

Frontiers in pediatrics 20220509

<h4>Objective</h4>To explore the correlation between serum 25-hydroxyvitamin D levels and tic disorders (TDs) in Chinese children.<h4>Methods</h4>We selected 2960 children with TD and 2665 healthy controls, aged 5-14 years, from the Department of Neurology of the Shanghai Children's Hospital. Serum 25-hydroxyvitamin D levels and degrees of vitamin D deficiency were compared between patients with TD and healthy children.<h4>Results</h4>The mean serum 25-hydroxyvitamin D level in the TD group was ...[more]

PMID: 35615632

Similar Datasets

Project description:BackgroundPrevious studies on the liner associations between serum 25-hydroxyvitamin D [25(OH)D] levels and lipid profiles revealed ambiguous findings. The current study therefore tried to elucidate the possible non-linear associations between 25(OH)D and lipid profiles.MethodsThis study involved 8,516 adult participants (aged 18-74 years, males N = 3,750, females N = 4,766) recruited from the Dalian health management cohort (DHMC). The risk (OR) for specific dyslipidemias was estimated across the serum 25(OH)D levels and the cut-off value for serum 25(OH)D were determined by using logistic regression, restricted cubic spline, and piecewise linear regression methods, adjusted for age, sex, season, and ultraviolet index.ResultsIn this study, a high prevalence of 25(OH)D deficiency was observed in the participants (65.05%). The level of 25(OH)D showed the inverse U-shaped correlations with the risks (ORs) of abnormal lipid profile, with inflection points observed at 23.7 ng/ml for hypercholesterolemia, 24.3 ng/ml for hypertriglyceridemia, 18.5 ng/ml for hyper-low-density lipoprotein cholesterolemia, 23.3 ng/ml for hypo-high-density lipoprotein cholesterolemia, 23.3 ng/ml for hyper-non-high-density lipoprotein cholesterol, and 24.3 ng/ml for high remnant cholesterol. The stratified analyses showed that the risk for most dyslipidemias related to deficiency of 25(OH)D was particularly increased among females aged 50-74 (except for hypertriglyceridemia, where the highest risk was among men aged 50-74 years), during winter/spring or under low/middle ultraviolet index environments.ConclusionsNonlinear inverse U-shaped associations were observed between 25(OH)D levels and abnormal lipid profile. The risk was particularly increased among females aged 50-74, during winter/spring period or under lower ultraviolet index environments. In vitamin D deficient subjects [25(OH)D <20 ng/ml], a positive association of serum vitamin D levels with the risk for dyslipidemia was observed, which needs a further.

Dataset Information

Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children.

Objective

Methods

Results

Conclusion

Publications

Correlation Between Tic Disorders and Serum 25-Hydroxyvitamin D Levels in Chinese Children.

Similar Datasets

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