Ontology highlight
ABSTRACT:
SUBMITTER: Bishop B
PROVIDER: S-EPMC2709225 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Bishop Benjamin B Aricescu A Radu AR Harlos Karl K O'Callaghan Chris A CA Jones E Yvonne EY Siebold Christian C
Nature structural & molecular biology 20090628 7
Hedgehog (Hh) morphogens have fundamental roles in development, whereas dysregulation of Hh signaling leads to disease. Multiple cell-surface receptors are responsible for transducing and/or regulating Hh signals. Among these, the Hedgehog-interacting protein (Hhip) is a highly conserved, vertebrate-specific inhibitor of Hh signaling. We have solved a series of crystal structures for the human HHIP ectodomain and Desert hedgehog (DHH) in isolation, as well as HHIP in complex with DHH (HHIP-DHH) ...[more]