Ontology highlight
ABSTRACT:
SUBMITTER: Klejnot M
PROVIDER: S-EPMC3266853 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Klejnot Marta M Kozielski Frank F
Acta crystallographica. Section D, Biological crystallography 20120113 Pt 2
Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melanogaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to f ...[more]