Ontology highlight
ABSTRACT:
SUBMITTER: Johnson AD
PROVIDER: S-EPMC2709290 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Johnson A D AD Gong Y Y Wang D D Langaee T Y TY Shin J J Cooper-Dehoff R M RM Schork N J NJ Binkley P P Pepine C J CJ Johnson J A JA Sadee W W
Clinical pharmacology and therapeutics 20081022 1
Genetic variants of ACE are suspected risk factors in cardiovascular disease, but the alleles responsible for the variations remain unidentified. To search for regulatory polymorphisms, allelic angiotensin I-converting enzyme (ACE) mRNA expression was measured in 65 heart tissues, followed by genotype scanning of the ACE locus. Marked allelic expression imbalance (AEI) detected in five African-American subjects was associated with single-nucleotide polymorphisms (SNPs) (rs7213516, rs7214530, and ...[more]