Ontology highlight
ABSTRACT:
SUBMITTER: Chung CM
PROVIDER: S-EPMC3587614 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chung Chia-Min CM Wang Ruey-Yun RY Fann Cathy S J CS Chen Jaw-Wen JW Jong Yuh-Shiun YS Jou Yuh-Shan YS Yang Hsin-Chou HC Kang Chih-Sen CS Chen Chien-Chung CC Chang Huan-Cheng HC Pan Wen-Harn WH
PloS one 20130304 3
Angiotensin-converting enzyme (ACE) has been implicated in multiple biological system, particularly cardiovascular diseases. However, findings associating ACE insertion/deletion polymorphism with hypertension or other related traits are inconsistent. Therefore, in a two-stage approach, we aimed to fine-map ACE in order to narrow-down the function-specific locations. We genotyped 31 single nucleotide polymorphisms (SNPs) of ACE from 1168 individuals from 305 young-onset (age ≤40) hypertension ped ...[more]